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Tesemorelin 20mg — GHRH Analogue (GRF 1-44 Modified) — Research Grade

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Research-grade Tesemorelin 20mg — a synthetic GHRH analogue (GRF 1-44, modified) targeting the GHRH receptor on pituitary somatotroph cells. HPLC-verified at >99% purity. Lyophilised, UK next-day dispatch. Available as Vial, Cartridge, or Disposable Pen. Strictly for in-vitro laboratory research. Not for human consumption.

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Growth & Performance Range

Tesemorelin — GHRH Analogue

GRF(1-44) Modified Research Peptide  ·  20mg Research Vial

Available Formats

Vial
Lyophilised powder vial offering full flexibility in reconstitution volume and concentration.

Cartridge (Reusable Pen)
Pre-filled replacement cartridge compatible with standard reusable research pens. Pen sold separately.

Disposable Pen
Fully pre-loaded, self-contained research pen. Ready to use directly from packaging.


Compound Overview

Tesemorelin is a synthetic analogue of human growth hormone-releasing hormone (GHRH), comprising the full 44-amino-acid GRF(1-44) sequence with an N-terminal trans-3-hexenoic acid modification that enhances metabolic stability. It was developed by Theratechnologies Inc. and has been the subject of multiple clinical trials investigating its effects on the GH-IGF-1 axis.

The 20mg format provides a standard research unit suitable for dose-response studies, receptor binding assays, and comparative protocols against shorter GHRH fragments such as CJC-1295 (Mod GRF 1-29).

Mechanism of Action

GHRH Receptor Activation: Tesemorelin binds to and activates the GHRH receptor (GHRH-R) on anterior pituitary somatotroph cells. GHRH-R is a G-protein coupled receptor that signals through the cAMP/PKA pathway, stimulating pulsatile growth hormone gene transcription and secretion.

Full-Length vs Fragment: As a full-length GRF(1-44) analogue, Tesemorelin retains all receptor-binding and signalling domains of the native GHRH molecule. The trans-3-hexenoic acid modification reduces susceptibility to dipeptidyl peptidase-IV (DPP-IV) cleavage, extending the compound’s functional half-life compared to unmodified GHRH.

Published Research

  • Falutz J et al. (2007) — JAMA, 298(22): 2647-2655. Phase 3 trial evaluating Tesemorelin’s effects on the GH-IGF-1 axis and body composition parameters.
  • Stanley TL et al. (2014) — The Lancet Diabetes and Endocrinology, 2(11): 896-905. Extended evaluation of Tesemorelin in clinical research settings.

Note: Citations are provided for reference purposes only. BioCompounds UK does not make therapeutic claims.

Structural & Chemical Data

Compound ClassModified GHRH analogue (GRF 1-44)
Molecular TargetGHRH-R (Growth Hormone-Releasing Hormone Receptor)
ModificationN-terminal trans-3-hexenoic acid
Purity>99% verified by HPLC
Quantity20mg per unit
SolubilitySterile water / PBS
Storage (Dry)-20 C
Storage (Reconstituted)2-8 C, use within 4 weeks

Regulatory & Usage Notice

This product is supplied strictly as a research-grade reference compound for in-vitro laboratory investigation only. It is not approved, intended, or marketed for human or veterinary administration, diagnostic purposes, or therapeutic application. Purchasers must be qualified researchers aged 18+ and agree to handle all compounds in accordance with applicable regulations and good laboratory practice (GLP). BioCompounds UK makes no therapeutic claims regarding this or any compound in its catalogue.

Frequently Asked Questions

What is Tesemorelin?

Tesemorelin (also written Tesamorelin) is a synthetic growth-hormone-releasing hormone analogue based on the GRF(1-44) sequence with a stabilising modification. It binds the GHRH receptor and is studied in pulsatile GH release research.

What is the purity of this peptide?

BioCompounds UK supplies HPLC-verified research-grade material. Selected batches undergo independent third-party analysis by Janoshik Analytical, with current published Certificates of Analysis available on our batch verification page when applicable.

What is the half-life of Tesemorelin?

Tesemorelin has a relatively short half-life of approximately 30 minutes, similar to native GHRH. Research protocols typically involve daily administration to model physiological GH pulses.

How does Tesemorelin compare to CJC-1295?

Both are GHRH-receptor agonists studied for GH release. Tesemorelin is based on the full GRF(1-44) sequence; CJC-1295 (No DAC) is the shorter GRF(1-29) analogue. Tesemorelin has the most extensive clinical research record of the two.

How should this peptide be stored?

Storage depends on the format you have chosen:

  • 20mg Vial (lyophilised powder): Store at -20°C in a sealed container, away from light and moisture. Once reconstituted, keep refrigerated between 2°C and 8°C and use within approximately four weeks.
  • 3ml Cartridge (for reusable pen): Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.
  • Disposable Ready-to-Use Pen: Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.

Full details are in our Peptide Storage Guide.

What formats is this available in?

This product is available in three research formats: a 20mg lyophilised vial, a 3ml cartridge for reusable research pens, and a ready-to-use disposable pen. Vials offer the most flexibility in reconstitution; cartridges and pens are calibrated for our standard equipment.

How fast is UK delivery?

Orders are typically dispatched within 24 hours via Royal Mail Tracked 24. During busier periods dispatch may extend to 48 hours. Free shipping on UK orders over £100. Full details on our Postage Guidance page.

Is this product legal in the UK?

All BioCompounds UK products are sold strictly for in-vitro laboratory research by qualified researchers aged 18 or over. They are not approved or intended for human or veterinary consumption, diagnostic, or therapeutic use. See our Terms of Purchase for full guidance.

Weight0.050 kg

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