Semax 10mg — BioCompounds UK product tile

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Semax 10mg — ACTH(4-10) Fragment Analogue — Research Grade

Name: Semax 10mg — ACTH(4-10) Fragment Analogue — Research Grade
Brand: BioCompounds UK
SKU: BCUK-355
Price: 19.99 GBP
Availability: InStock

Price range: £19.99 through £39.99 inc. VAT

Free shipping on orders over £100

Research-grade Semax 10mg — a synthetic heptapeptide analogue of the ACTH(4-10) fragment. Investigated in preclinical research for its interaction with neurotrophic factor signalling pathways. HPLC-verified at >99% purity. UK next-day dispatch. Available as Vial, Cartridge, or Disposable Pen. Strictly for in-vitro laboratory research. Not for human consumption.

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SKU: N/A Categories: Full Range, Mind Health Tags: 99%+ HPLC purity, in vitro research, lyophilised peptide, neuropeptide, neuropeptide research, research peptide, UK research use only Brand: Bio Compounds UK - BCUK

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Cognitive & Sleep Range

Semax — ACTH(4-10) Fragment Analogue

Nootropic Research Peptide · 10mg Research Vial

Available Formats

Vial
Lyophilised powder vial offering full flexibility in reconstitution.

Cartridge (Reusable Pen)
Pre-filled cartridge compatible with standard reusable research pens. Pen sold separately.

Disposable Pen
Pre-loaded, self-contained research pen. Ready to use from packaging.

Compound Overview

Semax is a synthetic heptapeptide based on the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) with a C-terminal Pro-Gly-Pro extension that confers resistance to enzymatic degradation. It was originally developed at the Institute of Molecular Genetics, Russian Academy of Sciences, and has been the subject of preclinical and clinical research primarily in Russian and European scientific literature.

Unlike full-length ACTH, Semax does not interact with melanocortin receptors associated with adrenal steroidogenesis. Its pharmacological profile has been studied independently of the hypothalamic-pituitary-adrenal (HPA) axis.

Mechanism of Action

Neurotrophic Factor Expression: Preclinical studies have reported that Semax modulates the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in rodent models. BDNF is a key regulator of synaptic plasticity, neuronal survival, and differentiation in neuroscience research.

Monoaminergic Modulation: Research in animal models has observed effects on dopaminergic, serotonergic, and noradrenergic neurotransmission following Semax administration, with regional specificity in the hippocampus and prefrontal cortex.

Neuropeptide Processing: Semax has been studied for its influence on endogenous neuropeptide processing enzymes, including carboxypeptidase E and prolyl endopeptidase, which play roles in neuropeptide maturation.

Published Research

Dolotov OV et al. (2006) — Neuroscience Letters, 399(3): 210-215. Effects of Semax on BDNF expression in rat brain.
Grivennikov IA et al. (2008) — Doklady Biological Sciences, 421: 258-260. Gene expression profiling following Semax administration in rodent cortical neurons.

Note: Citations provided for reference only. BioCompounds UK does not make therapeutic claims.

Structural & Chemical Data

Compound Class	ACTH(4-10) fragment analogue (heptapeptide)
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Purity	>99% verified by HPLC
Quantity	10mg per unit
Solubility	Sterile water / PBS
Storage (Dry)	-20 C
Storage (Reconstituted)	2-8 C, use within 4 weeks

Regulatory & Usage Notice

This product is supplied strictly as a research-grade reference compound for in-vitro laboratory investigation only. It is not approved, intended, or marketed for human or veterinary administration, diagnostic purposes, or therapeutic application. Purchasers must be qualified researchers aged 18+ and agree to handle all compounds in accordance with applicable regulations and good laboratory practice (GLP). BioCompounds UK makes no therapeutic claims regarding this or any compound in its catalogue.

Frequently Asked Questions

What is Semax?

Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-10) with a stabilising C-terminal Pro-Gly-Pro modification. It is studied in nootropic, neuroprotective, and BDNF-signalling research models. Originally developed in Russia.

What is the purity of this peptide?

BioCompounds UK supplies HPLC-verified research-grade material. Selected batches undergo independent third-party analysis by Janoshik Analytical, with current published Certificates of Analysis available on our batch verification page when applicable.

What is the half-life of Semax?

Semax has a short systemic half-life (minutes), but its modulation of BDNF and other neurotrophin signalling persists much longer. Daily intranasal administration is the most common research protocol.

How does Semax compare to Selank?

Both are short Russian-developed regulatory peptides studied in neurobehavioural research. Semax (ACTH-derived) is more often studied in cognition, BDNF, and neuroprotection contexts. Selank (tuftsin-derived) is more often studied in anxiolytic and immunomodulatory contexts. See our Semax vs Selank comparison.

How should this peptide be stored?

Storage depends on the format you have chosen:

5mg or 10mg Vial (lyophilised powder): Store at -20°C in a sealed container, away from light and moisture. Once reconstituted, keep refrigerated between 2°C and 8°C and use within approximately four weeks.
3ml Cartridge (for reusable pen): Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.
Intranasal Research Apparatus (10mg/10ml): Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep upright and away from light.

Full details are in our Peptide Storage Guide.

What formats is this available in?

This product is available in multiple research formats: a 5mg lyophilised vial, a 10mg lyophilised vial, a 10mg 3ml cartridge for reusable research pens, and a 10mg/10ml intranasal research apparatus. The intranasal format is the most commonly cited in published Semax research literature.

How fast is UK delivery?

Orders are typically dispatched within 24 hours via Royal Mail Tracked 24. During busier periods dispatch may extend to 48 hours. Free shipping on UK orders over £100. Full details on our Postage Guidance page.

Is this product legal in the UK?

All BioCompounds UK products are sold strictly for in-vitro laboratory research by qualified researchers aged 18 or over. They are not approved or intended for human or veterinary consumption, diagnostic, or therapeutic use. See our Terms of Purchase for full guidance.

Weight	0.050 kg

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Semax 10mg — ACTH(4-10) Fragment Analogue — Research Grade