MT-2 — Melanocortin Receptor Agonist
Cyclic Heptapeptide Research Compound · 10mg Research Vial
Available Formats
Vial
Lyophilised powder vial offering full flexibility in reconstitution volume and concentration.
Cartridge (Reusable Pen)
Pre-filled replacement cartridge compatible with standard reusable research pens. Pen sold separately.
Disposable Pen
Fully pre-loaded, self-contained research pen. Ready to use directly from packaging.
Nasal
Pre-prepared nasal delivery format for intranasal administration research protocols.
Compound Overview
MT-2 (Melanotan II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH). It was originally developed at the University of Arizona by Hruby and Hadley in the 1990s as a research tool for studying melanocortin receptor pharmacology.
MT-2 is a non-selective melanocortin receptor agonist with affinity for multiple MCR subtypes (MC1R, MC3R, MC4R, MC5R). Its broad receptor binding profile has made it a widely used pharmacological tool in melanocortin system research.
Receptor Pharmacology
MC1R: Expressed on melanocytes and immune cells. MC1R activation is the primary pathway studied in melanogenesis and pigmentation research.
MC3R: Expressed in the hypothalamus and peripheral tissues. Investigated in energy homeostasis and autonomic function research.
MC4R: Expressed in central nervous system regions including the hypothalamus and brainstem. MC4R is a major research target in neuroendocrine signalling studies.
MC5R: Expressed in sebaceous glands and other exocrine tissues. Studied for its role in exocrine gland function research.
Published Research
- Hruby VJ et al. (1995) — Journal of Medicinal Chemistry, 38(18): 3454-3461. Design and synthesis of MT-2 as a melanocortin receptor research tool.
- Dorr RT et al. (1996) — Life Sciences, 58(20): 1777-1784. Pharmacological evaluation of MT-2 in preclinical models.
Note: Citations are provided for reference purposes only. BioCompounds UK does not make therapeutic claims.
Structural & Chemical Data
| Compound Class | Non-selective melanocortin receptor agonist |
| Structure | Cyclic heptapeptide (lactam bridge) |
| Receptor Targets | MC1R, MC3R, MC4R, MC5R |
| Purity | >99% verified by HPLC |
| Quantity | 10mg per unit |
| Solubility | Sterile water / PBS |
| Storage (Dry) | -20 C |
| Storage (Reconstituted) | 2-8 C, use within 4 weeks |
Regulatory & Usage Notice
This product is supplied strictly as a research-grade reference compound for in-vitro laboratory investigation only. It is not approved, intended, or marketed for human or veterinary administration, diagnostic purposes, or therapeutic application. MT-2 is not an approved medicine in the UK or EU. Purchasers must be qualified researchers aged 18+ and agree to handle all compounds in accordance with applicable regulations and good laboratory practice (GLP). BioCompounds UK makes no therapeutic claims regarding this or any compound in its catalogue.








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