The three Bio Compounds UK supply formats side by side: ready-to-use disposable pen, vial, and cartridge for a re-usable pen

KPV 30mg — Alpha-MSH C-Terminal Tripeptide (CAS 67727-97-3) — Research Grade

Name: KPV 30mg — Alpha-MSH C-Terminal Tripeptide (CAS 67727-97-3) — Research Grade
Brand: BioCompounds UK
SKU: BCUK-4008
Price: 39.99 GBP
Availability: InStock

Price range: £39.99 through £59.99 inc. VAT

Free shipping on orders over £100

Research-grade KPV 30mg — alpha-MSH C-terminal tripeptide (Lys-Pro-Val), CAS 67727-97-3. HPLC-verified at >99% purity. Lyophilised, UK next-day dispatch. Available as Vial, Cartridge, or Disposable Pen. Strictly for in-vitro laboratory research. Not for human consumption.

Earn up to 180 points.

Options

Clear

- +

SKU: N/A Categories: Full Range, Longevity, Tissue Tags: 99%+ HPLC purity, alpha-MSH analogue, anti-ageing research, in vitro research, lyophilised peptide, melanocortin receptor agonist, research peptide, tissue repair, UK research use only Brand: Bio Compounds UK - BCUK

View Certificate of Analysis (COA)

Tissue & Recovery Range

KPV — Alpha-MSH C-Terminal Tripeptide

Melanocortin-Independent Research Peptide · 30mg Research Vial

Available Formats

Vial	Lyophilised powder vial offering full flexibility in reconstitution volume and concentration.
Cartridge (Reusable Pen)	Pre-filled replacement cartridge compatible with standard reusable research pens. Pen sold separately.
Disposable Pen	Fully pre-loaded, self-contained research pen. Ready to use directly from packaging.

Compound Overview

KPV (Lysine-Proline-Valine) is a synthetic tripeptide corresponding to the C-terminal fragment (residues 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH). Unlike the full-length alpha-MSH tridecapeptide, KPV does not bind melanocortin receptors (MCRs), indicating its biological activity operates through a distinct, receptor-independent mechanism.

KPV has been studied in preclinical research models since the 1980s, with particular focus on NF-kB pathway modulation and inflammatory signalling cascades.

Mechanism of Action

NF-kB Pathway Modulation: In vitro studies have demonstrated that KPV can enter cells and directly interact with components of the NF-kB signalling cascade, including inhibition of IKK-beta phosphorylation and nuclear translocation of the p65 subunit. This mechanism has been characterised as melanocortin receptor-independent (Kannengiesser et al., 2008).

Intracellular Uptake: Research suggests KPV enters cells via peptide transporter PepT1 (SLC15A1), a proton-coupled oligopeptide transporter expressed in intestinal epithelium and other tissues. This transporter-mediated uptake has been studied as a model for oral peptide bioavailability.

Published Research

Brzoska T et al. (2008) — Endocrine Reviews, 29(5): 581-602. Review of alpha-MSH and related peptides in preclinical research models.
Kannengiesser K et al. (2008) — Journal of Molecular Medicine, 86(12): 1307-1318. Investigation of KPV transport and NF-kB modulation mechanisms.

Note: Citations are provided for reference purposes only. BioCompounds UK does not make therapeutic claims.

Structural & Chemical Data

Compound Class	Alpha-MSH C-terminal tripeptide fragment
CAS Number	67727-97-3
Sequence	Lys-Pro-Val
Purity	>99% verified by HPLC
Quantity	30mg per unit
Solubility	Sterile water / PBS
Storage (Dry)	-20 C
Storage (Reconstituted)	2-8 C, use within 4 weeks

Regulatory & Usage Notice

This product is supplied strictly as a research-grade reference compound for in-vitro laboratory investigation only. It is not approved, intended, or marketed for human or veterinary administration, diagnostic purposes, or therapeutic application. Purchasers must be qualified researchers aged 18+ and agree to handle all compounds in accordance with applicable regulations and good laboratory practice (GLP). BioCompounds UK makes no therapeutic claims regarding this or any compound in its catalogue.

Frequently Asked Questions

What is KPV?

KPV is a tripeptide consisting of lysine, proline, and valine (Lys-Pro-Val). It is the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH) and is studied for its anti-inflammatory signalling in research models, particularly in epithelial and gastrointestinal contexts.

What is the purity of this peptide?

BioCompounds UK supplies HPLC-verified research-grade material. Selected batches undergo independent third-party analysis by Janoshik Analytical, with current published Certificates of Analysis available on our batch verification page when applicable.

What is the half-life of KPV?

KPV has a short systemic half-life, but published research typically focuses on tissue-level effects rather than circulating pharmacokinetics. Research protocols often use daily administration.

How is KPV related to alpha-MSH?

KPV represents the final three amino acids of alpha-MSH. It retains some of the parent peptide’s anti-inflammatory activity in research models without engaging melanocortin receptors directly, making it a useful tool for isolating C-terminal-mediated pathways. See our KPV research guide for more.

How should this peptide be stored?

Storage depends on the format you have chosen:

30mg Vial (lyophilised powder): Store at -20°C in a sealed container, away from light and moisture. Once reconstituted, keep refrigerated between 2°C and 8°C and use within approximately four weeks.
3ml Cartridge (for reusable pen): Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.
Disposable Ready-to-Use Pen: Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.

Full details are in our Peptide Storage Guide.

What formats is this available in?

This product is available in three research formats: a 30mg lyophilised vial, a 3ml cartridge for reusable research pens, and a ready-to-use disposable pen. Vials offer the most flexibility in reconstitution; cartridges and pens are calibrated for our standard equipment.

How fast is UK delivery?

Orders are typically dispatched within 24 hours via Royal Mail Tracked 24. During busier periods dispatch may extend to 48 hours. Free shipping on UK orders over £100. Full details on our Postage Guidance page.

Is this product legal in the UK?

All BioCompounds UK products are sold strictly for in-vitro laboratory research by qualified researchers aged 18 or over. They are not approved or intended for human or veterinary consumption, diagnostic, or therapeutic use. See our Terms of Purchase for full guidance.

Weight	0.050 kg

Reviews

There are no reviews yet

Add a review

Currently, we are not accepting new reviews

KPV 30mg — Alpha-MSH C-Terminal Tripeptide (CAS 67727-97-3) — Research Grade