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IGF-1 LR3 — Long Arg3 Insulin-Like Growth Factor 1MG — Research Grade

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Research-grade IGF-1 LR3 — an 83-amino-acid analogue of insulin-like growth factor 1 with Arg3 substitution and 13-AA N-terminal extension for reduced IGFBP binding. >99% HPLC purity. Strictly for in-vitro laboratory research. Not for human consumption.

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IGF-1 LR3 — Long Arg3 Insulin-Like Growth Factor

Growth Factor Research Peptide  ·  1mg Research Vial

Compound Overview

IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor 1) is a synthetic 83-amino-acid analogue of human IGF-1. Two structural modifications distinguish it from native IGF-1: a glutamic acid to arginine substitution at position 3 (Arg3), and a 13-amino-acid N-terminal extension peptide. These modifications reduce binding affinity for IGF-binding proteins (IGFBPs), increasing free-fraction bioavailability in research models.

Mechanism of Action

IGF-1 Receptor (IGF-1R): IGF-1 LR3 activates the IGF-1 receptor, a receptor tyrosine kinase that signals through PI3K/Akt and Ras/MAPK cascades. IGF-1R signalling is a central subject in cell proliferation, differentiation, and survival research.

Reduced IGFBP Binding: The Arg3 substitution and N-terminal extension reduce affinity for IGFBPs 1-6, resulting in a higher free fraction compared to native IGF-1. This property makes IGF-1 LR3 a useful research tool for studying IGF-1R activation independent of IGFBP sequestration.

Published Research

  • Francis GL et al. (1992) — J Mol Endocrinol, 8(3):213-223. Characterisation of IGF-1 LR3 binding properties and biological activity.

Citations for reference only. No therapeutic claims.

Regulatory Notice

Strictly for in-vitro laboratory investigation only. Not for human or veterinary use. BioCompounds UK makes no therapeutic claims.

Frequently Asked Questions

What is IGF-1 LR3 and what does it target?

IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor 1) is a modified analogue of native IGF-1. It binds the IGF-1 receptor (IGF-1R) with comparable affinity to wild-type IGF-1 but, due to reduced binding to IGFBP-3 carrier protein, exhibits a longer functional half-life in research models.

What is the purity of this peptide?

BioCompounds UK supplies HPLC-verified research-grade material. Selected batches undergo independent third-party analysis by Janoshik Analytical, with current published Certificates of Analysis available on our batch verification page when applicable.

What is the half-life of IGF-1 LR3?

IGF-1 LR3 has an approximate functional half-life of 20-30 hours, considerably longer than native IGF-1 (~15 minutes). Daily administration is the typical pattern in published research protocols.

How does IGF-1 LR3 differ from native IGF-1?

The “LR3” modification refers to an N-terminal extension and an Arg substitution at position 3. These changes substantially reduce binding to insulin-like growth factor binding proteins, increasing the proportion of free, bioactive peptide in research models. See our IGF-1 LR3 guide for more.

How should this peptide be stored?

Storage depends on the format you have chosen:

  • 1mg Vial (lyophilised powder): Store at -20°C in a sealed container, away from light and moisture. Once reconstituted, keep refrigerated between 2°C and 8°C and use within approximately four weeks.
  • 3ml Cartridge (for reusable pen): Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.
  • Disposable Ready-to-Use Pen: Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.

Full details are in our Peptide Storage Guide.

What formats is this available in?

This product is available in three research formats: a 1mg lyophilised vial, a 3ml cartridge for reusable research pens, and a ready-to-use disposable pen. Vials offer the most flexibility in reconstitution; cartridges and pens are calibrated for our standard equipment.

How fast is UK delivery?

Orders are typically dispatched within 24 hours via Royal Mail Tracked 24. During busier periods dispatch may extend to 48 hours. Free shipping on UK orders over £100. Full details on our Postage Guidance page.

Is this product legal in the UK?

All BioCompounds UK products are sold strictly for in-vitro laboratory research by qualified researchers aged 18 or over. They are not approved or intended for human or veterinary consumption, diagnostic, or therapeutic use. See our Terms of Purchase for full guidance.

Weight0.050 kg
Standard

1 mg Vial, Cartridge for Re-usable Pen, Ready to use Disposable Pen

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