5-Amino-1MQ — NNMT Inhibitor
NAD+ Salvage Pathway Modulator · 50mg Research Vial
Available Formats
Vial — Lyophilised powder vial offering full flexibility in reconstitution volume and concentration.
Cartridge (Reusable Pen) — Pre-filled replacement cartridge compatible with standard reusable research pens. Pen sold separately.
Disposable Pen — Fully pre-loaded, self-contained research pen. Ready to use directly from packaging.
Compound Overview
5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine (SAH). By inhibiting this reaction, 5-Amino-1MQ has been studied as a research tool for probing the methyl donor pool, NAD+ salvage flux, and adipocyte energy metabolism.
The compound has been characterised in published preclinical literature as a selective, cell-permeable NNMT inhibitor with reported low-micromolar potency in biochemical and cellular assays.
Mechanism of Action
Research has identified several pathways associated with 5-Amino-1MQ activity in preclinical models:
NNMT Inhibition: 5-Amino-1MQ binds the nicotinamide-binding pocket of NNMT, competitively reducing methylation of nicotinamide. This preserves intracellular nicotinamide available for NAD+ salvage via NAMPT and NMNAT pathways.
Methyl Donor Pool Preservation: By limiting consumption of SAM, NNMT inhibition has been associated in cell models with elevated SAM:SAH ratios, a key index of cellular methylation capacity.
Adipocyte Energy Metabolism: Studies in diet-induced obese mouse models have reported reductions in adipose tissue mass and improvements in metabolic parameters following 5-Amino-1MQ administration, attributed to enhanced fatty-acid oxidation in white adipose tissue.
Published Research
Neelakantan H et al. (2018) — Biochemical Pharmacology, 147: 141-152. Small-molecule NNMT inhibitor activates the methyl cycle in adipocytes, reduces fat mass, and improves diet-induced obesity in mice.
Kannt A et al. (2018) — Scientific Reports, 8: 3660. Selective NNMT inhibition leads to NAD+ salvage modulation in adipose tissue.
Note: Citations are provided for reference purposes only. BioCompounds UK does not make therapeutic claims based on published research data.
Structural & Chemical Data
| Compound Class | Quinolinium small molecule (NNMT inhibitor) |
| CAS Number | 102877-32-9 |
| Molecular Formula | C₁₀H₁₁IN₂ |
| Molecular Weight | 286.11 g/mol |
| Purity | >99% verified by HPLC |
| Form | Lyophilised powder (vial) / Pre-filled solution (cartridge & pen) |
| Quantity | 50mg per unit |
| Solubility | Sterile water / DMSO |
| Origin | EU |
| LOT / Specimen No. | 06-26 |
| Storage (Dry) | -20°C |
| Storage (Reconstituted) | 2-8°C, use within 4 weeks |
Regulatory & Usage Notice
This product is supplied strictly as a research-grade reference compound for in-vitro laboratory investigation only. It is not approved, intended, or marketed for human or veterinary administration, diagnostic purposes, or therapeutic application. Purchasers must be qualified researchers aged 18+ and agree to handle all compounds in accordance with applicable regulations and good laboratory practice (GLP). BioCompounds UK makes no therapeutic claims regarding this or any compound in its catalogue.
Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). By blocking NNMT-mediated nicotinamide methylation, it is studied for its role in cellular NAD+ salvage pathways and metabolic research models.
What is the purity of this peptide?
BioCompounds UK supplies HPLC-verified research-grade material. Selected batches undergo independent third-party analysis by Janoshik Analytical, with current published Certificates of Analysis available on our batch verification page when applicable.
What is the half-life of 5-Amino-1MQ?
5-Amino-1MQ is a small molecule rather than a peptide and has a relatively short half-life in research models, typically requiring daily administration in published protocols.
How does 5-Amino-1MQ relate to NAD+ research?
NNMT consumes nicotinamide and a methyl group from SAM. Inhibiting NNMT preserves nicotinamide for NAD+ salvage and reduces SAM depletion. This positions 5-Amino-1MQ as a research tool for investigating NAD+ homeostasis alongside direct NAD+ precursors. See our 5-Amino-1MQ guide.
How should this peptide be stored?
Storage depends on the format you have chosen:
- 50mg Vial (lyophilised powder): Store at -20°C in a sealed container, away from light and moisture. Once reconstituted, keep refrigerated between 2°C and 8°C and use within approximately four weeks.
- 3ml Cartridge (for reusable pen): Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.
- Disposable Ready-to-Use Pen: Store refrigerated between 2°C and 8°C from arrival. Once opened, use within 3 months. Keep away from light.
Full details are in our Peptide Storage Guide.
What formats is this available in?
This product is available in three research formats: a 50mg lyophilised vial, a 3ml cartridge for reusable research pens, and a ready-to-use disposable pen. Vials offer the most flexibility in reconstitution; cartridges and pens are calibrated for our standard equipment.
How fast is UK delivery?
Orders are typically dispatched within 24 hours via Royal Mail Tracked 24. During busier periods dispatch may extend to 48 hours. Free shipping on UK orders over £100. Full details on our Postage Guidance page.
Is this product legal in the UK?
All BioCompounds UK products are sold strictly for in-vitro laboratory research by qualified researchers aged 18 or over. They are not approved or intended for human or veterinary consumption, diagnostic, or therapeutic use. See our Terms of Purchase for full guidance.
Freshly made and very effective.